“For all agents, the magnitude of the toxicity increases with concentration.” (more…), May 19, 2018 3:57 pm / 2 Comments on Head Pain is a diagnostic feature of Gadolinium Deposition Disease. With the current status of understanding gadolinium toxicity by the medical community, there is no known or verified methods to know with absolute certainty if you are gadolinium toxic or have symptoms that are caused by the element. Intense boring pain in bones or joints. As with most medical conditions, the specific symptoms of Gadolinium Toxicity will vary from person to person. Several of the papers cited by Marckmann were referenced in my 2012 letter to the FDA to make my point that gadolinium retention could happen to ALL patients and they could be adversely affected by it. I believe the “N” in NSF sent us down the wrong path and it has caused many patients who have retained gadolinium not to be properly diagnosed simply because they did not have impaired kidney function or NSF-like skin changes. Recent Viewpoints. ( Log Out / symptoms of Gadolinium Toxicity. Primer on gadolinium chemistry. Since the medical community believes these contrast dyes are harmless, many don’t trace their symptoms back on their timeline to their scan. Updated Gadolinium Retention test result information is also presented. Depending on how much gadolinium someone retains and where it has been deposited in their body, the patient could experience many new symptoms or a few. Symptoms of Gadolinium Toxicity/Gadolinium Deposition Disease. Some have also described a persistent metallic taste or olfactory sensation. The literature also indicates that gadolinium is neurotoxic, nephrotoxic, and cytotoxic, it inhibits mitochondrial function, induces oxidative stress, triggers endoplasmic reticulum stress, increases vascular reactivity, induces macrophage apoptosis, causes fatty liver, is a potent blocker of calcium channels, and more. Mai 2018 2. The median lethal dose (LD50) of Gadolinium is roughly 100-200 mg/kg of body weight, but the dosage used for each MRI scan with contrast falls under this threshold.According to earlier studies, GBCA toxicity depends not on the presence of gadolinium, but on the strength of the chelating agent. Materials and methods: This HIPAA-compliant, IRB-approved study consisted of an anonymous online survey of patients who believe that they suffer from gadolinium toxicity. Gadolinium Deposition Disease (GDD) refers to patients with gadolinium accumulation having normal kidney function that show painful symptoms within few hours or weeks or two months after exposure to Gadolinium based contrast agents (GBCAs). Let’s not allow the name of a disease and how it is defined result in patients not having their gadolinium-induced symptoms and related health issues properly recognized and treated. Affected patients and their loved ones may be able to file a lawsuit and recover damages. Gadolinium Toxicity: If not NSF, then what is it? Gadolinium and systemic fibrosis: guilt by association. It describes “phases of NSF” and a “severity grading”, and the paper highlights the differences between early and late manifestations of the disease. Arising in early stage (early on after GBCA): This can be any bones or any joints. Symptoms. He said that it is imperative that individuals have at least 3 of the symptoms, but he prefers to see 5/6 to be certain of the diagnosis. www.GadoliniumToxicity.com, on Possible connection between GBCAs and Small Fiber Neuropathy, on Head Pain is a diagnostic feature of Gadolinium Deposition Disease. Most of the gadolinium toxicity affected patients I know describe their chronic pain as a dull, continuous ache, and as burning, numbness, prickling sensations, electric-like feelings, and/or deep bone pain in their hips, joints, and ribs. Retrieved from http://ard.bmj.com/content/69/11/1895.full.pdf, Marckmann, P., & Skov, L. (2009). The symptoms experienced could vary and might not be uniform among all patients. Any bones can have severe point pain, but rib pain is quite distinctive for the disease. Burning, itching or severe sharp pai… That is not a novel idea since it was suggested by some doctors in the past, including Dr. Jonathan Kay and his colleagues who said, “NSF neither originates in the kidney nor is caused by factors originating in the kidney”. Reports of possible clinical symptoms experienced by patients after a contrast-enhanced MRI have been published. Gadolinium toxicity Symptoms include pain in the skin, bones, joints or head. My hope is that more research will be conducted that involves evaluation and testing of patients who have retained gadolinium and are experiencing SFN-like symptoms, which, until now, have been unexplained and perplexing to clinicians who are not familiar with the potential toxic effects of retained gadolinium. Symptoms of NSF are very similar to the symptoms of gadolinium poisoning. With all of that published evidence of gadolinium’s toxic effects, I don’t believe it should come as a surprise to anyone that patients are reporting a wide range of symptoms after their MRIs with a gadolinium-based contrast agent – if anything, it seems it should be expected. As Sherry et al. The long-term and cumulative effects of retained gadolinium in the brain and elsewhere are not as yet understood. Just as Marckmann and Skov said about NSF, the clinical picture of Gadolinium Toxicity is diversified, and it varies from one patient to another and it varies over time. The updated graphs show an even stronger pattern of Gadolinium urine levels based on the number of months since the participant’s last Contrast MRI. We know from the NSF-related literature that gadolinium can cause a potentially fatal systemic disease process when it is retained in the human body. At the beginning, that made sense since the problem only had been seen in patients with end-stage renal disease (ESRD). Gadolinium Toxicity has been linked to several medical conditions such as Nephrogenic Systemic Fibrosis, Gadolinium Deposition Disease and Gadolinium Storage Condition. Coauthor of The Lighthouse Project The development of symptoms such as headaches, bone/joint pain and skin changes appear to occur earlier, with typical onset times reported between hours and days post-contrast-enhanced MRI [ 24, 25 ]. SIGNIFICANCE: Significant differences in gadolinium levels in bone and urine are observed between individuals experiencing symptoms of gadolinium toxicity and for those who are not exhibiting symptoms. One only needs to read the NSF autopsy-based review articles to know that gadolinium can affect every organ in the body and cause extensive fibrosis and calcification of tissues. The symptoms in Gadolinium deposition disease are similar to nephrogenic systemic fibrosis (NSF) but are less severe. They found a significant increase of TAS/IEFND for the linear GBCAs, whereas only a “trend without significance” was found for the macrocyclic agents. I believe part of the problem stems from the fact that histopathological examination has not found any evidence that deposited Gd caused “harm” in the brain. Do we need more research to understand the scope of the problem or just more awareness and acceptance of what has already been published about gadolinium toxicity and NSF? Georg 30. The authors made an important point that I believe should apply to all patients who have had MRIs with a GBCA. Nephrogenic systemic fibrosis (NSF) Causes the skin and internal organs to harden. Nephrogenic systemic fibrosis can begin days to months after exposure to gadolinium-containing contrast. The study, Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases with Reduced Kinetic Stability of the Agent, was published online ahead of print in Investigative Radiology. Gd-induced Systemic Fibrosis…If that name change had been made in 2009, perhaps gadolinium retention and the chronic symptoms and health issues experienced by patients with normal renal function would have been recognized much longer ago, and more time and resources could have been spent on trying to find a cure and better treatments for all affected patients. Often the joints may be peripheral but can also be large joints like the knee or hip. Click here for more information on Gadolinium toxicity and for support from others going through the same problems. Absence of potential gadolinium toxicity symptoms following 22,897 gadoteric acid (Dotarem®) examinations, including 3,209 performed on renally insufficient individuals Instead of woodiness, doughiness; instead of redness, pinkness; instead of extreme joint contractures, stiffness of joints and decreased range of motion. Could it just be that the connection has not yet been made, and when considered together, all these facts might explain how patients’ symptoms are being caused by retained Gd from gadolinium-based contrast agents (GBCAs)? Most doctors know absolutely nothing about gadolinium toxicity. Head pain (early on after GBCA). If that was the case in full-blown NSF, when the patient likely retained a lot more gadolinium, think how retaining less gadolinium might impact the clinical picture of patients with normal or near-normal renal function. Gadolinium levels in urine and gadolinium concentration in bone were found to have a non-significant relationship (R 2 = 0.11, p = 0.3). As we have said many times before, Gadolinium Toxicity is a “disease of degrees” which we believe causes a disease process of varying severity with NSF likely being the most severe manifestation of it, but there is no reason to think it will be the only one. The name can limit the scope of medical research, and when it comes to gadolinium, it has the potential to exclude other patient populations who have been exposed to the same toxic metal. Nephrogenic systemic fibrosis: clinical picture and treatment. 6. Brain fog is also a prominent feature of lead toxicity, which is another heavy metal toxicity. Gadolinium was Retained in the Spinal Cord & Peripheral Nerves of Rats The presence of the gadolinium-based contrast agent depositions in the brain and symptoms of gadolinium neurotoxicity - A systematic review. Their self-reported symptoms have recently been published. Copyright 2014-2020, All Rights Reserved. Gadolinium (Gd) Result 1.2 Reference Interval < 0.8 ... Gadolinium has no known biological role in humans. Since we launched our website in 2014, there has been a significant amount of new research published that indicates that gadolinium is being deposited in the brain. is available for download as a PDF and it will be posted in Our Research in the Research section of our website. There are now 6 symptoms that stand out to Dr. Semelka as critical diagnostic findings for GDD. Intense burning of the skin and skin substrate. The long-term and cumulative effects of retained gadolinium in the brain and elsewhere are not as yet understood. Journal of Magnetic Resonance Imaging : JMRI, 30(6), 1240–8. By means of a symptom survey of 17 people with high urine levels of Gadolinium, we have provided a comprehensive review of this topic in Survey of the Chronic Effects of Retained Gadolinium from Contrast MRIs, which we encourage you to read. Research efforts should focus on trying to find ways to mitigate the problem and treat the symptoms associated with Gadolinium Toxicity. These symptoms include the following: Pain and a burning sensation in the lower arms and lower limbs – patients often describe the pain as burning or cutting Pain in the bones or joints www.GadoliniumToxicity.com. In 2016, a paper was published that provided the initial description of what is being called Gadolinium Deposition Disease or GDD in patients with normal or near normal kidney function; the description was recently updated. The updated graphs show an even stronger pattern of Gadolinium urine levels based on the number of months since the participant’s last Contrast MRI. What difference does a name make? For a companion editorial on this topic by Hubbs Grimm, my partner on GadoliniumToxicity.com, read “Gadolinium Toxicity – Let’s not make the same mistake again”. I believe many symptoms of gadolinium toxicity can be explained by Gd-induced small fiber neuropathy (SFN) and long-standing neuropathic pain. Gadolinium Deposition Disease (GDD) refers to patients with gadolinium accumulation having normal kidney function that show painful symptoms within few hours or weeks or two months after exposure to Gadolinium based contrast agents (GBCAs). used a mouse model to assess intraepidermal nerve fiber density (IENFD) after injection of gadolinium-based contrast agents (GBCAs). Posts about Symptoms written by Sharon Williams. Other than what you will read here and in our research papers, there is no published listing of the common symptoms of Gadolinium Toxicity. Meist zeigen sich erste Symptome bereits innerhalb weniger Stunden nach der Verabreichung eines MRT-Kontrastmittels, verstärken sich für einige Tage bis Wochen nach dessen Erhalt und chronifizieren auf … Symptoms of Gadolinium Toxicity: Can their cause be explained? I/we knew they were wrong about that, but because of what had been said repeatedly in the published literature, patients with normal kidney function could not convince doctors that their symptoms were connected to the MRI with contrast that they had. You may have to undergo an additional dialysis if all the gadolinium was not removed from your body, in which case gadolinium poisoning will occur on and around the access site. Skin tightness is a feature of GDD as well. shedding light on the effects of retained gadolinium from Contrast MRI. those patients with only one or two chronic symptoms of gadolinium toxicity, or another disease such as MS, won’t meet the diagnostic criteria for GDD. Headache is both a very common occurrence and shows tremendous variability. Change ), You are commenting using your Twitter account. You can absorb cesium by eating, drinking, breathing, or making skin contact with cesium or things containing its compounds. Arising in early stage (early on after GBCA): Many terms have been used for this: mental confusion sounds more scientific, but brain fog gets the point across well and succinctly. On this page, we … Less serious side effects nausea, headache and dizziness. Why should patients with normal kidney function be expected to be any different when they retain gadolinium? As of August 2018, governing authorities still have not recognized that patients with normal kidney function are being harmed by the gadolinium they are retaining. The FDA warning that came in 2015 was the one gadolinium toxicity advocates like Marcie were fighting for. This likely explains those patients’ symptoms of gadolinium toxicity. Dabei wurden alle in der Routine verwendeten Kontrastmittel in der zugelassenen Dosierung hinsichtlich Verträglichkeit, Nebenwirkungsprofil und diagnostischer Wirksamkeit lange Zeit als sicher eingestuft. In 1997, when a group of patients on dialysis developed what appeared to be a new skin disorder, it was called Nephrogenic Fibrosing Dermopathy (NFD). After all, we have been down this road before with NSF/NFD. They can be very intense soon after the MRI. Updated Gadolinium Retention test result information is also presented. Skin that may feel \"woody\" and develop an orange-peel appearance and darkening (excess pigmentation) 4. Arising in early stage (early on after GBCA): This can be an all over feeling in the body, but often may be localized to the trunk region or distal extremities. The authors noted that the cause of SFN remains unknown in up to 50% of cases. A 2009 paper by Marckmann and Skov, “Nephrogenic Systemic Fibrosis: Clinical Picture and Treatment”, provides some important insight into other aspects of NSF beyond just the expected biopsy findings. These symptoms may represent part of the same process that is causing brain fog. As a possible additional marker for damage of small fibers, the appearance of terminal axonal swellings (TASs) was assessed. Like what happened with NSF, all patients affected by retained gadolinium may not be properly diagnosed, and the effects of gadolinium toxicity will continue to be underreported. I believe the time has come for researchers and the FDA to acknowledge that evidence of gadolinium retention is evidence of harm…period. For more information about NSF, GBCAs, and Gadolinium, please see the Background section of our website. Absence of potential gadolinium toxicity symptoms following 22,897 gadoteric acid (Dotarem®) examinations, including 3,209 performed on renally insufficient individuals Eur Radiol. Radiologic Clinics of North America, 47(5), 833–40, vi. Interestingly, as you will see in my letter, many symptoms of SFN are the same as the clinical symptoms associated with nephrogenic systemic fibrosis (NSF), which makes sense to me since the cause is the same. Isn’t it logical to think that lesser amounts of retained gadolinium could cause similar but perhaps less severe damage to various body systems in almost every patient who retains it? Radbruch and his colleagues investigated changes of small fibers in the epidermis of mice as a potential cause of patient complaints about burning pain in their arms and legs after administration of a GBCA. Our only advice is to consider symptom relief carefully, and do not try to be the hero who says “I … Nephrogenic systemic fibrosis can begin days to months after exposure to gadolinium-containing contrast. Gadolinium, used in dyes to increase the clarity of MRI and MRA scans, can create chemical element retention in the body, Therefore, this increases the risk of gadolinium deposition disease. Particularly as this experiment has been done on 300-400 million people who weren't aware of this, they were only warned it may retain if their kidney was damaged and it may then have fatal consequences in that case (NSF). The problem has nothing to do with patients’ kidneys, but everything to do with retained gadolinium – a toxic metal like lead or mercury. I understand the logic behind that, but don’t we already have scientific evidence? GDD sufferers describe it as a head pain, and unlike any other type of head-ache they have previously experienced. The FDA acknowledging that Gadolinium (a highly toxic heavy metal) is retaining in healthy men, women and children's brains, organs, bones and tissues is HUGE. Gadolinium Toxicity Symptoms. If we had known from the beginning in 1997 that retained gadolinium was the cause, maybe it would have been called gadolinium toxicity or gadolinium poisoning and not NFD or NSF. Instead of naming a “new” gadolinium-related disease, perhaps NSF should be renamed once again to make the name reflect the fact that impaired kidney function was not the cause of it. Toxicity is rarely associated with Gd due to its poor gastrointestinal absorption (it is suspected that very little Gd is absorbed from the gastrointestinal tract (<0.05%). The symptoms of Gadolinium Toxicity can include: Pain in the arms and legs (more…). The literature also indicates that gadolinium is neurotoxic, nephrotoxic, and cytotoxic, it inhibits mitochondrial function, induces oxidative stress, triggers endoplasmic reticulum stress, increases vascular reactivity, induces macrophage apoptosis, causes fatty liver, is a potent blocker of calcium channels, and more. This study provides the first definitive evidence that GBCAs induce mitochondrial toxicity and cell death in cultured human neurons. That diagnostic criteria should be applied to every patient who has evidence of gadolinium retention after their MRI with contrast and any unexplained symptoms. First, symptoms of GDD must start within minutes to one month after administration of a gadolinium-based contrast agent (GBCA). So the good news is that there are relatively few commercial uses for this dangerous metal and its compounds (1). What we don’t know is how much they retain. Muscle vibrations/twitching and pins and needles skin sensations generally reflect nerve disease (neuropathy). Gadolinium deposition disease refers to situations in which a person has normal or adequate renal function but develops persistent and/or painful symptoms anywhere from a few hours to several weeks after being injected with a gadolinium contrast agent. Symptoms often develop within a month or so of the MRI. 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